Postdoctoral Fellowship in Developmental Biology

A two-year postdoctoral position supported by the French Foundation for Medical Research (FRM) is
available starting September 1st 2018 to work in the group Gene regulatory networks, axis specification
and morphogenesis of the sea urchin embryo at the Institute of Biology Valrose in Nice.
The area of research will concern the analysis of transcriptional regulation downstream of Nodal and
BMP2/4 signalling in the sea urchin embryo (see Lapraz F, Haillot E, and Lepage,T – 2015 - A
deuterostome origin of the Spemann organiser suggested by Nodal and ADMPs functions in
Echinoderms; Nature communications and Haillot E, Molina MD, Lapraz F, and Lepage,T (2015) The
Maternal Maverick/GDF15-like TGF-β Ligand Panda Directs Dorsal-Ventral Axis Formation by Restricting
Nodal Expression in the Sea Urchin Embryo. - 2015 - PLoS Biology.

Project description:
Our laboratory has recently generated high-quality data of chromatin accessibility in wild type embryos
and following over-activation of the Nodal and BMP2/4 pathways by ATAC-seq. In addition, we have
recently obtained high-quality developmental transcriptomes and a high-quality genome assembly for
the Mediterranean sea urchin Paracentrotus lividus. The availability of these resources as well as the
availability of the genome sequence of several sea urchins offers a unique opportunity to dissect
complex gene regulatory networks.
The postdoctoral project will aim at integrating the results of these “omics” screens in the analysis of the
dorsal-ventral gene regulatory network of the sea urchin embryo. In particular, the project will focus on
exploring the regulatory landscapes associated with Nodal and BMP signaling and at identifying the cisregulatory
modules of the Nodal and BMP2/4 target genes. Another goal is to identify the transcription
factors regulating nodal expression identified by ATAC-seq. Finally, this project offers a unique
opportunity to investigate how chromatin accessibility is modulated during the process of cell fate
specification and determination.

Qualifications
Candidates should have obtained recently a PhD degree. Both national and international candidates are
encouraged to apply. Interested candidates should send a Curriculum Vitae, a summary of research
interests and goals and contact information for two or three referees to:
Dr Thierry Lepage *: tlepage@unice.fr