A two-year postdoctoral position supported by the French Foundation for Medical Research (FRM) is available starting September 1st 2018 to work in the group Gene regulatory networks, axis specification and morphogenesis of the sea urchin embryo at the Institute of Biology Valrose.
The area of research will concern the dissection of the Gene regulatory network regulating dorsalventral patterning of the sea urchin embryo (see Lapraz F, Haillot E, and Lepage,T – 2015 - A deuterostome origin of the Spemann organiser suggested by Nodal and ADMPs functions in Echinoderms; Nature communications and Haillot E, Molina MD, Lapraz F, and Lepage,T (2015) The Maternal Maverick/GDF15-like TGF-β Ligand Panda Directs Dorsal-Ventral Axis Formation by Restricting Nodal Expression in the Sea Urchin Embryo. - 2015 - PLoS Biology.
Our laboratory has recently performed large-scale transcriptomic screens to identify novel genes and small RNAs expressed downstream of Nodal and downstream of BMP2/4 signaling. In addition, we have recently obtained high-quality developmental transcriptomes and a high-quality genome assembly for the Mediterranean sea urchin Paracentrotus lividus. These new tools offer a unique opportunity to complement the existing Gene regulatory network (GRN). The postdoctoral project will aim at
integrating the results of these transcriptomic screens in the analysis of the dorsal-ventral gene regulatory network. In particular, the project will aim at validating the novel genes identified as bona fide targets of Nodal or BMP2/4 signaling by characterizing their expression and function. Epistasis analysis will allow to analyze their position in the gene regulatory and the information collected will be used to build a novel more complete version of the gene regulatory responsible for patterning the embryo along the D/V axis. Finally, this information will be incorporated into a new version of a logical qualitative model of the GRN that we have built in collaboration with the group of D. Thieffry and that captures the main properties of the network.
Candidates should have obtained recently a PhD degree. Both national and international candidates are encouraged to apply. Interested candidates should send a Curriculum Vitae, a summary of research interests and goals and contact information for two or three referees to:
Dr Thierry Lepage : firstname.lastname@example.org Research team webpage
Institut de Biologie Valrose, CNRS UMR7277 - Inserm U1091 - Université Nice Sophia Antipolis
Parc Valrose, 06108 NICE cedex 2 – France